Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus

Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus.

How the fetus escapes rejection by the maternal immune system remains one of the major unsolved questions in transplantation immunology. Using a system to visualize both CD4+ and CD8+ T cell responses during pregnancy in mice, we find that maternal T cells become aware of the fetal allograft exclusively through "indirect" antigen presentation, meaning that T cell engagement requires the uptake ...

Maternal Tolerance to the Allogeneic Fetus in Antigen-Hyporesponsive T Cells Induces Adoptive Transfer of Paternal

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چکیده ندارد.

Abortion-Prone Matings Maternal Tolerance to the Allogeneic Fetus in Antigen-Hyporesponsive T Cells Induces Adoptive Transfer of Paternal

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Residues within processed protein fragments bound to major histocompatibility complex class I (MHC-I) glycoproteins have been considered to function as a series of "independent pegs" that either anchor the peptide (p) to the MHC-I and/or interact with the spectrum of alphabeta-T-cell receptors (TCRs) specific for the pMHC-I epitope in question. Mining of the extensive pMHC-I structural database...